Longmire’s Lysis Buffer (pH 8.0) is designed for efficient cell lysis and stabilization of high-molecular-weight genomic DNA. The formulation facilitates disruption of cellular membranes while protecting DNA from degradation, making it suitable for sample collection, transport, and long-term storage prior to purification. Commonly used in molecular biology, environmental sampling, and diagnostic workflows, this ready-to-use buffer provides consistent and reliable performance for downstream applications such as PCR, sequencing, and genotyping.